P00520

Abl1

Tyrosine-protein kinase ABL1

1123 residues

Expression context

Soluble Membrane

63.4 Mean pLDDT (raw, whole protein)

1123 Residues

2 Folded domains

3 Constructs

3D Structure

Structure colored by pLDDT: blue = high confidence, orange/yellow = low

pLDDT Confidence

Per-residue confidence score. Dashed lines show construct boundaries.

Construct Suggestions

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core domain 62–512 451 residues

pLDDT (smoothed, this construct) 92.4

Trimmed low-confidence N-terminal tail (residues 1–61). Trimmed low-confidence C-terminal tail (residues 513–1123). Chose longest high-confidence segment (length 451). Note: start boundary at 62 falls inside SH3 domain (61-121).

core extended 59–514 456 residues

pLDDT (smoothed, this construct) 92.1

Trimmed low-confidence N-terminal tail (residues 1–58). Trimmed low-confidence C-terminal tail (residues 515–1123). Extended with moderate-confidence flanking regions for stability.

domain split 1019–1123 105 residues

pLDDT (smoothed, this construct) 82.3

Trimmed low-confidence N-terminal tail (residues 1–1018). Isolated domain (length 105) split by low-confidence linker.

Predicted Aligned Error (PAE)

The PAE matrix shows AlphaFold's confidence in the relative positioning of each pair of residues. Blue blocks along the diagonal indicate well-defined domains. Sharp boundaries between blocks suggest good places to cut constructs.